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KMID : 0604520190450020151
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 2 p.151 ~ p.159
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Glycation Inhibitory and Antioxidative Activities of Ergothioneine
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Bae Jun-Tae
Lee Cheong-Hee
Lee Geun-Soo
Kim Jin-Hwa
Hong Geun-Pyo
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Abstract
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Ergothioneine has been known as an excellent antioxidant and a cellular protector against oxidative damage in vivo. In the present study, ergothioneine was demonstrated to possess antioxidant and anti-glycation activities. The radical scavenging activity of ergothioneine enhanced the viability of human dermal fibroblasts (HDFs) exposed to ultraviolet (UV) light. The UVA irradiation increased the proportion of senescence-associated β-galactosidase (SA-β-gal) positive cells in comparison with the normal control group. The treatment of UVA-irradiated HDFs with ergothioneine decreased the level of SA-b-gal (by approximately 45% at an ergothioneine concentration of 400 μM) compared with the UVA-irradiated HDFs. We also found that ergothioneine inhibited production of glyceraldehyde-derived advanced glycation endproducts (AGEs) in a concentration-dependent manner. The ergothioneine educed carboxymethyl-lysine (CML) expression in comparison to the glyoxal treatment. In addition, in the Western blot analysis, treatment of glyoxal-stimulated HDFs with ergothioneine resulted in a dose-dependent decrease in the expression level of the receptor for AGE (RAGE). These results suggest that ergothioneine may have potent anti-aging effects and could be used as a cosmetic material against cellular accumulation of AGEs.
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KEYWORD
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ergothioneine, advanced glycation end products, anti-glycation, antioxidant, anti-aging
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